Lutetium 177 treatment

We found 30 clinics & 12 doctors for Lutetium therapy Worldwide. AiroMedical ranks among 437 hospitals based on qualification, experience, success rate, and awards.

Treatment with the radioactive isotope Lu-177 has shown promising outcomes. Especially in patients with advanced prostate cancer, neuroendocrine tumors (NET), and carcinoma of the kidneys (RCC) at varying phases, which include metastatic and recurrent forms. Medical trials have found that this new therapy works, is safe, and is well tolerated.

Oncologists try to get rid of cancer without hurting healthy tissues. So, traditional ways of doing things become less effective. Research focuses on specific target methods, and scientists look into more molecular radiotherapy options in nuclear medicine.

Lutetium-177 PSMA therapy is a treatment of radionuclide that the FDA has approved. It gathers in tumors and metastases, releasing beta particles that kill the cancer cells.

Radioactive particles, called radionuclides, are sent straight to the cancer cell. Radiation destroys the DNA in the tumor, which causes the cells to stop growing and die.

Radioligand therapy is the best way to treat advanced prostate cancer that has spread to other body parts, including neuroendocrine tumors and some kidney tumors. Radiopharmaceuticals find and kill all cancer cells in the body without harming healthy cells. That’s the way how is lutetium used in cancer therapy.

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Details of how Lutetium is used to achieve the target

The treatment helps down to the level of a microscope. Lutetium-177 binds to a carrier, which is the specific protein PSMA-617. It helps it find cancer cells. The molecule PSMA-617 builds up only tumor cells and doesn't hurt healthy tissues. It makes it possible to target cancerous tissue and avoid other cells.

Doctors found PSMA on cells that have prostate cancer. So, the tumor can spread to other parts of the body. With molecular radiotherapy, radiation directly affects cancer cells.

The professional gives PSMA Lutetium treatment at the hospital, and the patient stays there for three to five days. Under the supervision of a doctor, the drug is passed through an IV. After the course, oncologists perform control scintigraphy and PET-CT scans to determine how much the tumor and metastases have shrunk.

Also, many drug companies started making radioligands. In developed countries, Lutathera and Pluvicto are common brand names.

Who could need the procedure?

Each new method has a small range of uses. Even nuclear medicine doesn't stand out. So, it is evident that before searching a hospital or clinic, patients want to know what lutetium therapy is and in what cases it works.

Oncologists give Lu-177 PSMA treatment to people with metastatic castration-resistant prostate cancer (mCRPC) for the following:

  • When other possible ways to treat the problem don't work.
  • If standard alternatives to treatment aren't good enough for the patient.
  • Cases that are far along and moving quickly.
  • Surgery or regular radiation is out of the question.

Also, patients with neuroendocrine tumors (NET) and renal cell carcinoma (RCC) can try molecular radiotherapy. The range of treatments is still being looked into, and we can expect to be able to cure more diseases.

Most of the time, professionals do not use Lutetium as the "first line" of treatment. Instead, it's used after standard therapies have failed. But latest clinical studies have shown that advanced prostate cancer is getting better in a big way. So, the procedure can be used in the early stages of treatment, especially when there are metastases in distant places. Also, clinical trials look at breast cancer to see if it could be used in a targeted way.

There are different protocols for the world’s leading countries and hospitals. So, it makes sense to look abroad to see if you might be a candidate. There have been times when patients were told they needed radioligand treatment but could only get it abroad because of red tape.

Pros of Lutetium PSMA treatment

In oncology, people are searching for any help they can get. New treatments have many advantages over the old ones. Most of the time, regular procedures cause much harm to the body and are not targeted.

One of the primary reasons for making molecular treatments is to kill cancer on a micro level. Doctors can get great results with minimum difficulties.

There seem to be benefits to treatment with Lutetium-177-PSMA:

  1. Efficiency. The drug "finds" all cancerous cells, gathers them together, and kills them.
  2. Minimal hurt. Radiation is not given to the whole body, so healthy cells are not hurt.
  3. Safety. PSMA therapy is safe and well-liked by most people. It doesn't have any side effects that can't be fixed.
  4. Alternative. It works well when other treatments don't work for spreading prostate cancer.
  5. Choice. People who aren't good candidates for standard treatment can get this method.

Researchers claim that the Lutetium-177 life expectancy is increasing overall and progressive-free survival compared to standard therapy.

Some people can also use the treatment more than once. The sessions are done more than once, and even advanced cancer might be able to be treated.

Internment treatment has become very popular, especially for new methods. Patients in critical situations compare countries and hospitals to find the best solution. They are looking for Pluvicto and Luthatera can benefit from medical tourism.

Our company offers an opportunity to find the best provider of such therapy and organize a "door-to-door" service.

What about the side effects?

Radiotherapy is still what PSMA therapy is, despite its safety. So, there is a chance of damage from radiation. But it's been shown that it doesn't hurt healthy tissues. Most at risk are the cells in the renal tubules, small intestine, lacrimal glands, and salivary glands. So, the doctor will tell you about changing your lifestyle during the treatment. What to eat, how much to drink, and what to do to avoid or lessen the harmful impact.

Some people can use Lutetium as the last step after other treatments. So, the therapy might not work as planned on the body. That’s why before the procedure, experts check your main organs to prevent issues that could be life-threatening.

In addition to Lutetium treatment side effects, the procedure can make you feel tired, sick, throw up, and have headaches. Most of the time, general problems are uncommon and easy for doctors to handle.

After Lu 177, recovery

Some things can go wrong with the treatment. So, it's crucial to choose a skilled doctor and follow their instructions for cure and recovery. Before the patient leaves, they and the doctor talk in detail about whether or not the laboratory and instrumental diagnostic methods need to be done again. For example, renal scintigraphy could be used to check how well the kidneys work.

The analysis shows that a few days after the Lutetium-177 is put into the patient's body, the radiation from the tissues becomes very low and is no longer dangerous. Advisors say that the first few days of recovery should happen in the hospital after the treatment.

Patients usually go home after 24 to 48 hours. As suggested by the nuclear medicine doctor, patients should not do physical activity for the first few days after the treatment. A doctor will likely ask you to repeat scans and PSA tests to check how active your prostate cancer is.

FAQ

What does medicine do with Lutetium?

Lu-177 PSMA therapy is a new and promising way to treat metastatic or advanced prostate cancer when hormone therapy and chemotherapy no longer work. Neuroendocrine tumors and some kinds of renal cancer are also treated with it (renal cell carcinoma). At the moment, there are a lot of clinical trials planned to look for possible uses in breast cancer.

Is Lu-177 OK with the FDA?

The drug Lutetium-177 PSMA-617 can be used to treat prostate cancer that has spread and has the PSMA molecule on its surface (prostate-specific membrane antigen). It was approved on March 23, 2022, when Pluvicto was made.

Is there treatment for Lutetium in the US?

This year, 2022, the US Food and Drug Administration declared officially that Lutetium 177 could be used to treat prostate cancer. So, there are clinics that offer this method to their patients. But the process is easier to use and more affordable in Germany and other European countries.

How do you get Pluvicto?

The drug comes in a liquid form. It is given through an IV while being watched by a doctor. The infusion takes about 30 minutes. After that, the person is put in a special camera and left alone for a while.

Can Lutathera make you lose your hair?

Lutathera's most common side effects are vomiting, nausea, a drop in the number of blood cells, and an increase in liver enzymes and blood sugar. But it doesn't make you lose your hair.

Where can I get Lutetium therapy?

Germany, Turkey, Israel, Spain, Austria are among the best for Lutetium therapy.

How much does Lutetium-177 treatment cost?

The cost of the drug itself is one of the most significant parts of the total bill. But there are a lot of different components to the treatment. Typically, hospitals have to make the following:

  • Tests (PSMA PET CT scan, whole body or renal scintigraphy, urological and oncological examinations, blood tests, PSA and UA examination).
  • PSMA therapy with Lu-177.
  • Checkups after the fact.
  • Needed supplies and medicines.
  • A stay in the hospital and suggestions for more treatment.

So, the prices can range from $9,500 to $25,000 at various clinics. For example, Lutetium-PSMA therapy cost in Germany has one of the better price-quality ratios.

The cost can vary based on how many sessions are needed and whether or not the patient has had a recent PET-CT scan. Some cases may require more tests before and after treatment and possible medications to help with symptoms.

5 countries and 23 cities for Lutetium therapy