Necker-Enfants Malades University Hospital

Necker–Enfants Malades University Hospital (Hôpital universitaire Necker–Enfants malades, AP-HP) is a Paris-based academic tertiary-care center that serves as a major referral center for complex and high-acuity conditions, with a strong focus on pediatrics. It operates within the AP-HP hospital-university ecosystem, aligning specialist care with teaching and clinical research activity typical of a university hospital model. Clinically, Necker differentiates itself through an extensive pediatric portfolio that includes comprehensive pediatric medical and surgical specialties, supported by a dedicated pediatric emergency service. The emergency department is organized to receive children 24/7. It explicitly covers general pediatric emergencies as well as specialized pediatric ENT and pediatric neurosurgical emergencies, reinforcing its role as a high-capability front door for time-critical cases. Alongside pediatrics, the hospital maintains several adult services at a highly specialized level, particularly neurology, nephrology and kidney transplantation, hematology, and adult infectious diseases, creating an uncommon “mixed” profile in which select adult expert pathways coexist with a predominantly pediatric and mother–child mission. A core institutional strength is its concentration of rare-disease expertise and its integration of care with research platforms. AP-HP describes Necker as hosting close to 60 rare-disease reference or competence centers and highlights a care model built on synergy between clinical units, technical facilities, and research teams, with a substantial portfolio of ongoing clinical research projects. This translational orientation is further strengthened by the Imagine Institute's campus presence, which is designed to bring together research teams, reference centers, and clinical departments focused on genetic diseases, enabling tighter coupling between diagnostics, longitudinal specialist follow-up, and research protocols.