177 Lu-PSMA-617 Radioligand Therapy for Prostate Cancer | Saarland University Hospital

The nuclear medicine division at Saarland University Hospital stands as a global pillar of excellence for the treatment of advanced, metastatic castration-resistant prostate cancer. While many institutions have only recently adopted radioligand therapy, our team in Homburg has spent years refining the application of 177Lu-PSMA-617, establishing one of the highest-volume and academically significant programs in the world. Under the direction of internationally recognized pioneers in the field, patients gain access to a clinical environment where the specialized approach to individualized dosing and treatment intervals is utilized to achieve the best possible oncological outcomes while prioritizing the preservation of quality of life. The therapy itself targets the prostate-specific membrane antigen (PSMA), which is highly expressed on the surface of most prostate cancer cells. By injecting the 177Lu-PSMA-617 radioligand into the bloodstream, our specialists can deliver a targeted payload of beta radiation directly to tumor sites, regardless of their location in the body. This precision allows for the systematic destruction of bone and soft tissue metastases that are often resistant to traditional chemotherapy or hormonal treatments. At our clinic, the effectiveness of each cycle is meticulously tracked through advanced PET/CT imaging and PSA level monitoring, ensuring that the treatment plan remains responsive to the unique biological behavior of the patient’s disease. Safety and clinical rigor are the hallmarks of the Homburg experience. Patients are admitted to our state-of-the-art nuclear medicine therapy ward, where they are monitored by a multidisciplinary team of experts specifically trained in managing the nuances of radionuclide therapy. Unlike standard outpatient settings, our inpatient approach enables sophisticated dosimetry, the scientific calculation of the precise radiation dose delivered to the tumor versus healthy organs. This level of oversight is critical for protecting renal function and the salivary glands, ensuring that the treatment is as gentle as it is powerful. Our facility is designed to provide a calm, supportive atmosphere where medical safety and patient comfort are handled with equal importance.